The measurement of fractionated metanephrines in a 24-hour urine assortment is a medical diagnostic instrument employed to detect catecholamine-secreting tumors, similar to pheochromocytomas and paragangliomas. This take a look at quantifies the degrees of metanephrine and normetanephrine, that are metabolites of epinephrine (adrenaline) and norepinephrine (noradrenaline), respectively. Elevated ranges of those metabolites in urine can point out extreme catecholamine manufacturing, an indicator of those tumors.
Correct prognosis is essential as a result of untreated catecholamine-secreting tumors can result in extreme hypertension, cardiac arrhythmias, and even stroke. The historic growth of this take a look at has considerably improved the detection and administration of those probably life-threatening situations. Early and correct identification facilitates well timed intervention, together with surgical resection or medical administration to regulate catecholamine extra.