GPR91, also called succinate receptor 1 (SUCNR1), is a G protein-coupled receptor activated by succinate, an intermediate metabolite within the citric acid cycle. The very best achievable extent of GPR91 activation, typically termed its peak exercise or saturation level, represents the receptor’s most stage of response to succinate stimulation. This peak exercise is important for understanding the receptor’s physiological position. For example, in renal cells, the saturation level of GPR91 activation dictates the diploma of renin launch in response to elevated succinate concentrations.
Understanding the utmost stage of GPR91 exercise is essential for a number of causes. It permits researchers to quantify the complete potential impression of succinate signaling in varied tissues and illness states. Moreover, it’s important in drug growth, the place the efficacy of GPR91 agonists and antagonists should be evaluated relative to the receptor’s maximal capability. Traditionally, figuring out this worth has concerned refined biochemical assays to measure downstream signaling occasions, akin to intracellular calcium mobilization and cAMP manufacturing, throughout a variety of succinate concentrations.
