This assay quantifies a selected protein within the blood chargeable for transporting glucocorticoid hormones, corresponding to cortisol. This protein performs a vital function in regulating the bioavailability of those hormones, influencing their exercise in numerous tissues. For instance, low ranges of this protein can lead to larger ranges of free, unbound cortisol, probably resulting in scientific manifestations of hypercortisolism even when complete cortisol ranges seem regular. Conversely, elevated ranges can lower free cortisol, mimicking hypocortisolism.
Measurement of this protein is clinically important as a result of it aids within the correct evaluation of glucocorticoid standing. Its ranges are affected by quite a lot of situations, together with being pregnant, liver illness, thyroid problems, and genetic elements. Understanding its focus contributes to the proper prognosis and administration of endocrine problems, notably these associated to adrenal perform. Traditionally, evaluation of adrenal perform relied closely on complete cortisol measurements; nonetheless, recognizing the affect of this binding protein has refined diagnostic approaches.